ginsenoside-rb1 inhibition of vegf release – structure and activity relations (sar) perspective
نویسندگان
چکیده
editorial
منابع مشابه
Ginsenoside-Rb1 Inhibition of VEGF Release – Structure and Activity Relations (SAR) Perspective
Betts et al (2011) reported that Rb1 inhibits vascular endothelial growth factor (VEGF) release by retinal pigment epithelial cells, which is a major source of VEGF in the eye (1). Vascular endothelial growth factor is a proangiogenic cytokine that contributes significantly to pathological retinal and choroidal neovascularization in association with diabetic retinopathy and age-related macular ...
متن کاملGinsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release
Rb1, a ginsenoside from ginseng root extract, possesses antiangiogenic effects, but its role on ocular cells has not been studied. We hypothesize that Rb1 inhibits the production of the angiogenic cytokine VEGF from ARPE-19 cells, leading to a significant reduction in the proliferation of ocular vasculatures. Data from our experiments show that Rb1 induced an increase in the number of ARPE cell...
متن کاملEffects of Ginsenoside Rb1 on Skin Changes
Ginseng roots (Panax ginseng CA Meyer) have been used traditionally for the treatment, especially prevention, of various diseases in China, Korea, and Japan. Both experimental and clinical studies suggest ginseng roots to have pharmacological effects in patients with life-style-related diseases such as non-insulin-dependent diabetic mellitus, atherosclerosis, hyperlipidemia, and hypertension. T...
متن کاملAnti-apoptotic Activity of Ginsenoside Rb1 in Hydrogen Peroxide-treated Chondrocytes: Stabilization of Mitochondria and the Inhibition of Caspase-3
Chondrocyte apoptosis has been recognized as an important factor in the pathogenesis of osteoarthritis (OA). Hydrogen peroxide (H2O2), which produces reactive oxygen species, reportedly induces apoptosis in chondrocytes. The ginsenoside Rb1 (GRb1) is the principal component in ginseng and has been shown to have a variety of biological activities, such as anti-arthritis, anti-inflammation, and a...
متن کاملAntiobesity and Antihyperglycemic Effects of Ginsenoside Rb1 in Rats
OBJECTIVE Obesity and type 2 diabetes are national and worldwide epidemics. Because currently available antiobesity and antidiabetic drugs have limited efficacy and/or safety concerns, identifying new medicinal agents, such as ginsenoside Rb1 (Rb1) as reported here, offers exciting possibilities for future development of successful antiobesity and antidiabetic therapies. RESEARCH DESIGN AND M...
متن کاملMetabolism study of notoginsenoside R1, ginsenoside Rg1 and ginsenoside Rb1 of radix Panax notoginseng in zebrafish.
Zebrafish, a common model organism for studies of vertebrate development and gene function, has been used in pharmaceutical research as a new and powerful tool in recent years. In the present study, we applied zebrafish for the first time in a metabolic study of notoginsenoside (R1), ginsenoside (Rg1) and ginsenoside (Rb1), which are saponins isolated from Panax notoginseng. Metabolites of thes...
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عنوان ژورنال:
medical hypothesis, discovery and innovation ophthalmology journalجلد ۳، شماره ۲، صفحات ۳۸-۰
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